New Pyridinium Salt Derivatives of 2-(Hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide as Selective Inhibitors of Tumour-Related Human Carbonic Anhydrase Isoforms IX and XII.
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DOI: 10.2174/1871520622666220207092123
Abstract: BACKGROUND The positively charged membrane impermeant sulfonamides were evaluated as a remarkable class of carbonic anhydrase inhibitors (CAIs) previously. Without affecting the cytosolic isoforms hCA I and II, inhibition of two membrane-associated isoforms hCA IX… read more here.
Keywords: pyridinium; carbonic anhydrase; hca xii; isoforms hca ... See more keywords