6-Aryl Isoindolin-1-ones: Novel mGluR2 Negative Allosteric Modulators.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00106
Abstract: This highlight presents novel 6-aryl isoindolin-1-one derivatives that developed as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 2 (mGluR2). Chemical synthesis and potency (IC50) data for both mGluR2 and mGluR3 are disclosed. read more here.
Keywords: allosteric modulators; negative allosteric; aryl isoindolin; ones novel ... See more keywords
Isoindolin-1-ones Fused to Barbiturates: From Design and Molecular Docking to Synthesis and Urease Inhibitory Evaluation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01028
Abstract: Helicobacter pylori-induced ulcers and gastric cancer have been one of the main obstacles that the human community has ever struggled with, especially in recent decades. Several different attempts have been made to eradicate this group.… read more here.
Keywords: molecular docking; fused barbiturates; ones fused; urease inhibitory ... See more keywords
Co(ii)/Cu(ii)-cocatalyzed oxidative C-H/N-H functionalization of benzamides with ketones: a facile route to isoindolin-1-ones.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc02661d
Abstract: A cobalt and copper catalyzed reaction protocol has been developed to achieve the oxidative C-H/N-H annulation of benzamides containing an 8-aminoquinoline moiety as the directing group with ketones. Structurally diverse isoindolin-1-ones were furnished by the… read more here.
Keywords: oxidative functionalization; cocatalyzed oxidative; isoindolin ones; benzamides ketones ... See more keywords
The photodecarboxylative addition of carboxylates to phthalimides as a key-step in the synthesis of biologically active 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones
Sign Up to like & getrecommendations! Published in 2017 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.13.275
Abstract: The synthesis of various 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones was realized following a simple three-step process. The protocol utilized the photodecarboxylative addition of readily available carboxylates to N-(bromoalkyl)phthalimides as a versatile and efficient key step. The initially obtained hydroxyphthalimidines… read more here.
Keywords: dihydro isoindolin; synthesis; isoindolin ones; arylmethylene dihydro ... See more keywords