Synthesis and Computational Studies on Optoelectronically Important Novel Acridin-Isoindoline-1,3-Dione Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Fluorescence"
DOI: 10.1007/s10895-019-02376-2
Abstract: A series of novel 2-(4-(acridin-9-ylamino)phenyl)isoindoline-1,3-dione derivatives were designed and synthesized namely 2-(4-(4-methoxyacridin-9-ylamino)phenyl)isoindoline-1,3-dione [S1], 2-(4-(3-chloroacridin-9ylamino)phenyl)isoindoline-1,3-dione [S2], 2-(4-(2-fluor oacridin-9ylamino)phenyl)isoindoline-1,3-dione [S3], 2-(4-(1,4-dichloroacridin-9ylamino) phenyl)isoindoline-1,3-dione [S4]. The photophysical, thermal properties of these compounds were characterized by the spectroscopic and thermographic… read more here.
Keywords: novel acridin; isoindoline dione; phenyl isoindoline; dione derivatives ... See more keywords
Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.040
Abstract: Alzheimer's disease is characterized by chronic neurodegeneration leading to dementia. The main cause of neurodegeneration is considered to be the accumulation of amyloid-β. Inhibiting BACE1 is a well-studied approach to lower the burden of amyloid-β… read more here.
Keywords: dione framework; isoindoline dione; imidazopyridines containing; containing isoindoline ... See more keywords
Synthesis, spectra, electronic structure, molecular docking and cytotoxicity investigation on 2-(piperidin-1-ylmethyl)-isoindoline-1,3-dione – A Mannich base system
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129151
Abstract: Abstract A Mannich base molecule of 2-(piperidin-1-ylmethyl)isoindoline-1,3-dione (PPF) has been synthesized using Mannich base condensation reaction. The molecular geometry of PPF molecule was optimized by B3LYP/6-311G(d,p) basis set. The vibrational frequencies have been assigned with… read more here.
Keywords: piperidin ylmethyl; mannich base; isoindoline dione; base ... See more keywords
Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c8ra10532d
Abstract: A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via microwave heating and assayed for their anti-mycobacterial activities. read more here.
Keywords: anti mycobacterial; synthesis anti; isoindoline dione; dione aminoquinolines ... See more keywords
Synthesis and crystal structures of arylpiperazine compounds (“synthesis crystal structures arylpiperazine” for short)
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DOI: 10.1080/15421406.2017.1413223
Abstract: ABSTRACT Arylpiperazine derivatives referred in this article possessed antitumor activity, which were synthesized and crystallized through the gradual evaporation process. The molecular structures of 2-(4-(2-(4-phenylpiperazin-1-yl)ethyl)benzyl)isoindoline-1,3-dione (C27H27N3O2, 1), 2-(4-(2-(4-(4-bromophenyl)piperazin-1-yl)ethyl)benzyl)isoindoline-1,3-dione (C27H26BrN3O2, 2) and 2-(4-(2-(4-(4-chlorophenyl)piperazin-1-yl)ethyl)benzyl)isoindoline-1,3-dione (C27H26ClN3O2, 3) were… read more here.
Keywords: isoindoline dione; crystal structures; structures arylpiperazine; benzyl isoindoline ... See more keywords
Conformational dimorphism of 2,2′-methylenebis(isoindoline-1,3-dione)
Sign Up to like & getrecommendations! Published in 2019 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989018017425
Abstract: A new monoclinic polymorph of 2,2′-methylenebis(isoindoline-1,3-dione) with Z′ = 1 is reported. read more here.
Keywords: dimorphism methylenebis; methylenebis isoindoline; conformational dimorphism; isoindoline dione ... See more keywords
Crystal and Molecular Structure of 2-(4-Ethoxyphenyl)isoindoline-1,3-dione
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DOI: 10.1134/s1063774518070088
Abstract: The 2-(4-ethoxyphenyl)isoindoline-1,3-dione has been synthesized and characterized by X-ray single-crystal diffraction. The compound crystallizes in the orthorhombic sp. gr. Pna21 with four molecules in the unit cell and one molecule in the asymmetric unit. The… read more here.
Keywords: molecular structure; isoindoline dione; ethoxyphenyl isoindoline; structure ... See more keywords
Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry Central Journal"
DOI: 10.1186/s13065-018-0442-1
Abstract: Dioxoisoindolines have been included as a pharmacophore group in diverse drug-like molecules with a wide range of biological activity. Various reports have shown that phthalimide derivatives are potent inhibitors of AChE, a key enzyme involved… read more here.
Keywords: ache; isoindoline dione; dimethoxyphenyl ethyl; ethyl isoindoline ... See more keywords