1-Isoindolinone scaffold-based natural products with a promising diverse bioactivity.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104722
Abstract: Isoindolin-1-one or 1-isoindolinone framework is referred to phthalimidines or benzo fused γ-lactams of the corresponding γ-amino carboxylic acids and has been of prime interest for scientists for last several decades. 1-Isoindolinone framework is found in… read more here.
Keywords: isoindolinone scaffold; natural products; scaffold based; chemistry ... See more keywords
De novo Assembly of the Benzenoid Ring as a Core Strategy for Synthesis of the Isoindolinone Natural Products Isohericerin, Erinacerin A, and Sterenin A.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02752
Abstract: Here we describe the use of the hexadehydro-Diels-Alder (HDDA) reaction for the de novo construction of the isoindolinone scaffold and its application to the synthesis of the title natural products. The key isoindolinone-forming HDDA reaction… read more here.
Keywords: novo assembly; natural products; benzenoid ring; isoindolinone ... See more keywords
Chiral Brønsted Acid Catalyzed Enantioselective Synthesis of Spiro-Isoindolinone-Indolines via Formal [3 + 2] Cycloaddition.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00748
Abstract: A novel organocatalytic asymmetric formal [3 + 2] cycloaddition of 3-substituted 1H-indoles with in situ generated 3-hydroxy-isoindolinone-derived β,γ-alkynyl-α-ketimines has been developed. A variety of biologically relevant chiral spiro-isoindolinone-indolines were achieved with excellent yields (up to… read more here.
Keywords: isoindolinone; spiro isoindolinone; isoindolinone indolines; formal cycloaddition ... See more keywords
Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00569
Abstract: Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in signaling and repair of DNA single strand breaks. PARP-1 employs NAD+ to modify substrate proteins via the attachment of poly(ADP-ribose) chains. PARP-1 is a well established target… read more here.
Keywords: p515; inhibitor; nms p515; discovery stereospecific ... See more keywords