Chiral Brønsted Acid Catalyzed Enantioselective Synthesis of Spiro-Isoindolinone-Indolines via Formal [3 + 2] Cycloaddition.
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DOI: 10.1021/acs.orglett.2c00748
Abstract: A novel organocatalytic asymmetric formal [3 + 2] cycloaddition of 3-substituted 1H-indoles with in situ generated 3-hydroxy-isoindolinone-derived β,γ-alkynyl-α-ketimines has been developed. A variety of biologically relevant chiral spiro-isoindolinone-indolines were achieved with excellent yields (up to… read more here.
Keywords: isoindolinone; spiro isoindolinone; isoindolinone indolines; formal cycloaddition ... See more keywords