Activation of NQO-1 mediates the augmented contractions of isolated arteries due to biased activity of soluble guanylyl cyclase in their smooth muscle
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DOI: 10.1007/s00210-018-1548-7
Abstract: Earlier studies on isolated arteries demonstrated that the para-quinone thymoquinone, like acute hypoxia, induces augmentation of contractions, depending on biased activity of soluble guanylyl cyclase (sGC), generating inosine-3′,5′-cyclic monophosphate (cyclic IMP) rather than guanosine-3′,5′-cyclic monophosphate… read more here.
Keywords: augmented contractions; soluble guanylyl; isolated arteries; activity soluble ... See more keywords