Effects of cocaine and levamisole (as adulterant) on the isolated perfused Langendorff heart
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Legal Medicine"
DOI: 10.1007/s00414-020-02300-5
Abstract: Cocaine-related deaths occur regularly in forensic routine work. In cases in which the detected concentration of cocaine is rather low and other causes of death apart from intoxication can be ruled out, the question arises… read more here.
Keywords: heart; perfused langendorff; langendorff heart; cocaine ... See more keywords
The isolated perfused human skin flap model: A missing link in skin penetration studies?
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.10.003
Abstract: &NA; Development of effective (trans)dermal drug delivery systems requires reliable skin models to evaluate skin drug penetration. The isolated perfused human skin flap remains metabolically active tissue for up to 6 h during in vitro… read more here.
Keywords: flap; penetration; skin; human skin ... See more keywords
Validation of Methods for in Vitro-in Vivo Extrapolation Using Hepatic Clearance Measurements in Isolated Perfused Fish Livers.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c02656
Abstract: In vitro biotransformation assays using hepatocytes or liver subcellular fractions, combined with in vitro-in vivo extrapolation (IVIVE) models, have been proposed as an alternative to live fish bioconcentration studies. The uncertainty associated with IVIVE approaches… read more here.
Keywords: clearance; vitro vivo; hepatic clearance; vivo extrapolation ... See more keywords
Predicting Hepatic Clearance of Psychotropic Drugs in Isolated Perfused Fish Livers Using a Combination of Two In Vitro Assays.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c03017
Abstract: In vitro biotransformation assays with primary trout hepatocytes (RT-HEP) or liver subcellular fractions (RT-S9) have been proposed as valuable tools to help scientists and regulators better understand the toxicokinetics of chemicals. While both assays have… read more here.
Keywords: active transport; combination; isolated perfused; hepatic clearance ... See more keywords
Electrolyte handling in the isolated perfused rat kidney: demonstration of vasopressin V2-receptor-dependent calcium reabsorption
Sign Up to like & getrecommendations! Published in 2020 at "Upsala Journal of Medical Sciences"
DOI: 10.1080/03009734.2020.1804496
Abstract: Abstract Background The most profound effect of vasopressin on the kidney is to increase water reabsorption through V2-receptor (V2R) stimulation, but there are also data suggesting effects on calcium transport. To address this issue, we… read more here.
Keywords: calcium reabsorption; reabsorption; v2r stimulation; calcium ... See more keywords
An Isolated Perfused Rat Kidney Model for the Evaluation of the Effect of Glucose on Renal Tubular Epithelial Morphology
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DOI: 10.1111/1556-4029.13229
Abstract: An isolated perfused kidney model was used to evaluate the effect of hyperglycemia on renal tubular epithelial cell morphology. Ten Sprague–Dawley rat kidneys were perfused with Krebs–Henseleit buffer containing 70 mmol/L of glucose (five for… read more here.
Keywords: isolated perfused; renal tubular; kidney model; tubular epithelial ... See more keywords
The Etiology of Basal Vacuolizations in Renal Tubular Epithelial Cells Evaluated in an Isolated Perfused Kidney Model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.13354
Abstract: To determine whether basal lipid vacuolization characteristic of ketoacidosis could be induced with short‐term hypertriglyceridemia, adult Sprague Dawley rat kidneys were perfused in an isolated perfused kidney model with, and without, 11.3 mM (10 g/L)… read more here.
Keywords: etiology; isolated perfused; perfused kidney; vacuolization ... See more keywords
Pharmacokinetics of 99mTc-HMPAO in Isolated Perfused Rat Lungs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00717.2018
Abstract: Lung uptake of technetium-labeled hexamethylpropyleneamineoxime (HMPAO) increases in rat models of human acute lung injury, consistent with increases in lung tissue glutathione (GSH). Since 99mTc-HMPAO uptake is the net result of multiple cellular and vascular… read more here.
Keywords: pharmacokinetics 99mtc; lung uptake; hmpao; isolated perfused ... See more keywords
Glucagon and exenatide improve contractile recovery following ischaemia/reperfusion in the isolated perfused rat heart
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DOI: 10.14814/phy2.15597
Abstract: The inotropic effects of glucagon have been recognized for many years, but it has remained unclear whether glucagon signaling is beneficial to cardiac function. We evaluated the effects of glucagon alone and in combination with… read more here.
Keywords: reperfusion; glucagon; heart; isolated perfused ... See more keywords
Fundamentals and Applications of Isolated Perfused Lung (IPL) Model in the Development of Pulmonary Drug Delivery.
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DOI: 10.2174/1567201819666220823161318
Abstract: Estimating parameters such as pulmonary drug disposition and deposited dose, as well as determining the influence of pulmonary pharmacokinetics (PK) on drug efficacy and safety, are critical factors for the development of inhaled drug products… read more here.
Keywords: ipl model; pulmonary drug; lung; model ... See more keywords