Heterozygous Variants in FREM2 Are Associated with Mesiodens, Supernumerary Teeth, Oral Exostoses, and Odontomas
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13071214
Abstract: Background: Supernumerary teeth refer to extra teeth that exceed the usual number of dentitions. A mesiodens is a particular form of supernumerary tooth, which is located in the premaxilla region. The objective of the study… read more here.
Keywords: supernumerary teeth; oral exostoses; heterozygous variants; variants frem2 ... See more keywords
Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054255
Abstract: The activation of Wnt/β-catenin signalling is a prerequisite for odontogenesis. APC, a member of the AXIN-CK1-GSK3β-APC β-catenin destruction complex, functions to modulate Wnt/β-catenin signalling to establish regular teeth number and positions. APC loss-of-function mutations are… read more here.
Keywords: supernumerary teeth; mesiodens isolated; genetic variants; wnt catenin ... See more keywords