Isolation, synthesis, identification of new process-related impurities in evocalcet.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2022.114715
Abstract: Evocalcet is a calcimimetic for the treatment of secondary hyperparathyroidism. In the preparation of evocalcet, eleven process-related impurities were detected in the reaction solution of the last step at levels of 0.05%- 2.50% by a new… read more here.
Keywords: identification new; related impurities; isolation synthesis; synthesis identification ... See more keywords
Marine-derived Polyaromatic Butenolides - Isolation, Synthesis and Biological Evaluations.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical design"
DOI: 10.2174/1381612826666200518110617
Abstract: Marine invertebrates, especially tunicates, are a lucrative resource for the discovery of new lead compounds for the development of clinically utilized drugs. This review describes the isolation, synthesis and biological activities of several classes of… read more here.
Keywords: isolation synthesis; synthesis biological; derived polyaromatic; marine derived ... See more keywords