Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03051-2
Abstract: Huntington’s disease (HD) is a hereditary and fatal disease causing profound neurodegeneration. Deficits in cerebral energy and neurotransmitter metabolism have been suggested to play a central role in the neuronal dysfunction and death associated with… read more here.
Keywords: isoleucine; metabolism; huntington disease; chain amino ... See more keywords
Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Nmr"
DOI: 10.1007/s10858-019-00281-1
Abstract: Site specific methyl labeling combined with methyl TROSY offers a powerful NMR approach to study structure and dynamics of proteins and protein complexes of high molecular weight. Robust and cost-effective methods have been developed for… read more here.
Keywords: methyl; isoleucine; methyl labeling; pichia pastoris ... See more keywords
Intragastric administration of leucine and isoleucine does not reduce the glycaemic response to, or slow gastric emptying of, a carbohydrate-containing drink in type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2020.108618
Abstract: AIMS In healthy individuals, intragastric administration of the branched-chain amino acids, leucine and isoleucine, diminishes the glycaemic response to a mixed-nutrient drink, apparently by stimulating insulin and slowing gastric emptying, respectively. This study aimed to… read more here.
Keywords: isoleucine; glycaemic response; gastric emptying; leucine isoleucine ... See more keywords
3-Hydroxyisobutyrate Dehydrogenase Is Involved in Both, Valine and Isoleucine Degradation in Arabidopsis thaliana1[OPEN]
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DOI: 10.1104/pp.17.00649
Abstract: 3-Hydroxyisobutyrate dehydrogenase, an enzyme of the branched-chain amino acid breakdown pathway, is involved in valine and isoleucine but not in leucine degradation in Arabidopsis. In plants, amino acid catabolism is especially relevant in metabolic stress… read more here.
Keywords: hydroxyisobutyrate dehydrogenase; degradation; isoleucine; arabidopsis ... See more keywords