On the Mechanism and Origin of Isoleucyl-tRNA Synthetase Editing against Norvaline.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.01.029
Abstract: Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for coupling tRNAs to their cognate amino acids, minimize translational errors by intrinsic hydrolytic editing. Here, we compared norvaline (Nva), a linear amino acid not coded for protein synthesis,… read more here.
Keywords: editing nva; isoleucyl trna; trna synthetase; transfer editing ... See more keywords
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adc9249
Abstract: Development of antimalarial compounds into clinical candidates remains costly and arduous without detailed knowledge of the target. As resistance increases and treatment options at various stages of disease are limited, it is critical to identify… read more here.
Keywords: trna synthetase; cytoplasmic isoleucyl; resistance; drug ... See more keywords