Activation of PGC‐1α via isoliquiritigenin‐induced downregulation of miR‐138‐5p alleviates nonalcoholic fatty liver disease
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DOI: 10.1002/ptr.7334
Abstract: Nonalcoholic fatty liver disease (NAFLD), a metabolic disease, has received wide attention worldwide. However, there is no approved effective drug for NAFLD treatment. In the study, H&E and Oil Red O staining were employed to… read more here.
Keywords: nonalcoholic fatty; fatty liver; isoliquiritigenin; disease ... See more keywords
Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization
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DOI: 10.1080/10717544.2022.2096714
Abstract: Abstract Isoliquiritigenin (ISL), as a natural flavonoid, has been proven to have therapeutic potential for corneal neovascularization (CNV) treatment; however, its therapeutic use is restricted due to its poor aqueous solubility and limited bioavailability. To… read more here.
Keywords: corneal neovascularization; isl; treatment; isoliquiritigenin ... See more keywords
Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism
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DOI: 10.1155/2017/1379430
Abstract: Isoliquiritigenin (ISL), a natural antioxidant, has antitumor activity in different types of cancer cells. However the antitumor effect of ISL on human tongue squamous carcinoma cells (TSCC) is not clear. Here we aimed to investigate… read more here.
Keywords: tongue squamous; squamous carcinoma; microscopy; human tongue ... See more keywords
Dietary Isoliquiritigenin at a Low Dose Ameliorates Insulin Resistance and NAFLD in Diet-Induced Obesity in C57BL/6J Mice
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DOI: 10.3390/ijms19103281
Abstract: Isoliquiritigenin (ILG) is a flavonoid constituent of Glycyrrhizae plants. The current study investigated the effects of ILG on diet-induced obesity and metabolic diseases. C57BL/6J mice were fed a normal diet (AIN-76 purified diet), high-fat diet… read more here.
Keywords: c57bl mice; diet induced; resistance; induced obesity ... See more keywords
Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake
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DOI: 10.3390/molecules27217494
Abstract: Isoliquiritigenin (ISL) is a flavonoid with a chalcone structure extracted from the natural herb Glycyrrhiza glabra. Its anti-inflammatory, antibacterial, antioxidant, and anticancer activities have been extensively studied. Moreover, ISL also possess hypolipidemic and atherosclerosis-reducing effects.… read more here.
Keywords: effect; isoliquiritigenin; cholesterol uptake; pick like ... See more keywords