Isomer-driven supramolecular polymorphism of 4-hydroxytamoxifen modulating nanostructure-dependent cellular uptake and cytotoxicity.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale"
DOI: 10.1039/d5nr02944a
Abstract: Geometric isomerism in small-molecule drugs has traditionally been studied in the context of receptor binding or metabolic stability. However, its influence on supramolecular behavior and downstream biological function remains underexplored. Here, we investigate how the… read more here.
Keywords: supramolecular polymorphism; cytotoxicity; isomer; isomer driven ... See more keywords
Isomer-Driven Pyrazole Frameworks: Structural and Zwitterionic Insights for Advanced Energetics
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Materials Chemistry A"
DOI: 10.1039/d5ta00372e
Abstract: High-energy density materials (HEDMs) demand innovative molecular strategies for achieving optimized detonation performance, stability, and insensitivity. Now we present an isomer-driven design of two advanced energetic frameworks: high-energy compound 5,... read more here.
Keywords: pyrazole frameworks; zwitterionic insights; driven pyrazole; isomer driven ... See more keywords