Palladium-Catalyzed Isomerization/Hydrocarbonylation of Electron-Deficient Alkenes for the Construction of Lactones and Lactams.
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DOI: 10.1021/acs.orglett.4c03330
Abstract: An efficient palladium-catalyzed isomerization/hydrocarbonylation of electron-deficient alkenes was developed, affording a variety of benzofuran-2(3H)-ones, dihydrofuran-2(3H)-ones, indolin-2-ones, and isochroman-3-ones in high yields. The reaction exhibits excellent regioselectivity, high atom economy, and a broad range of substrates.… read more here.
Keywords: palladium catalyzed; isomerization hydrocarbonylation; hydrocarbonylation electron; electron deficient ... See more keywords