Synthesis and antimicrobial activity of a phenanthroline-isoniazid hybrid ligand and its Ag+ and Mn2+ complexes
Sign Up to like & getrecommendations! Published in 2019 at "BioMetals"
DOI: 10.1007/s10534-019-00204-5
Abstract: Hydrazide ligand, (Z)-N’-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag+ and Mn2+ complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1)2]NO3, [Ag(1)2]BF4 and [Mn(1)2](NO3)2. Polymeric {[Ag(1)(NO3)]}n has… read more here.
Keywords: isoniazid; antimicrobial activity; phenanthroline; mn2 complexes ... See more keywords
PBPK Analysis to Study the Impact of Genetic Polymorphism of NAT2 on Drug-Drug Interaction Potential of Isoniazid.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-03095-9
Abstract: PURPOSE Isoniazid (INH) is prescribed both for the prophylaxis as well as the treatment of tuberculosis. It is primarily metabolized through acetylation by a highly polymorphic enzyme, N-acetyl transferase 2 (NAT2), owing to which significant… read more here.
Keywords: isoniazid; cyp2c19 cyp3a4; study; drug ... See more keywords
Elevated homocarnosine and GABA in subject on isoniazid as assessed through 1H MRS at 7T.
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DOI: 10.1016/j.ab.2020.113738
Abstract: Typical magnetic resonance spectroscopy J-editing methods designed to quantify GABA suffer from contamination of both overlapping macromolecules and homocarnosine signal, introducing potential confounds. The aim of this study was to develop a novel method to… read more here.
Keywords: elevated homocarnosine; isoniazid; homocarnosine; homocarnosine gaba ... See more keywords
Protective effects of salep against isoniazid liver toxicity in wistar rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2017.06.001
Abstract: Introduction Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the… read more here.
Keywords: isoniazid; liver toxicity; salep; group ... See more keywords
Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2)
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DOI: 10.1016/j.lfs.2018.02.037
Abstract: Aims: Long‐term treatment of Isoniazid (INH) in tuberculosis (TB) patients can lead to anti‐tuberculosis drug‐induced hepatotoxicity. To understand the mechanism of hepatotoxicity, an attempt has been made to elucidate the role of Nrf2, a transcription… read more here.
Keywords: isoniazid; inh induced; role; factor ... See more keywords
Structural characterization and in-situ synthesis of quaternary ionic-cocrystal of isoniazid from un-ionized coformers
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DOI: 10.1016/j.molstruc.2021.130015
Abstract: Abstract Isoniazid is an important antitubercular compound and part of fixed-dose combinations (FDCs) that renders poor chemical stability to solid state form and has proved itself as a compound that successfully gives cocrystals with carboxylic… read more here.
Keywords: structural characterization; ionic cocrystal; cocrystal isoniazid; situ synthesis ... See more keywords
Differential Isoniazid Response Pattern Between Active and Dormant Mycobacterium tuberculosis.
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DOI: 10.1089/mdr.2020.0179
Abstract: Isoniazid (isonicotinic acid hydrazide, INH) is an effective frontline antituberculosis drug. INH targets several Mycobacterium tuberculosis processes, including mycolic acid biosynthesis, DNA synthesis, and redox potential. M. tuberculosis responds to INH stress by altering the… read more here.
Keywords: response pattern; pattern active; isoniazid; response ... See more keywords
Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid
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DOI: 10.1093/jac/dky378
Abstract: Objectives To describe the pharmacokinetics of isoniazid and acetyl-isoniazid in TB/HIV-coinfected patients, and assess the effects of efavirenz co-administration and a 50% increase in the dose of rifampicin on the pharmacokinetic parameters of isoniazid and… read more here.
Keywords: dose rifampicin; isoniazid; isoniazid acetyl; pharmacokinetics isoniazid ... See more keywords
Treatment With a Three-Drug Regimen for Pulmonary Tuberculosis Based on Rapid Molecular Detection of Isoniazid Resistance: A Noninferiority Randomized Trial (FAST-TB)
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DOI: 10.1093/ofid/ofac353
Abstract: Abstract Background The rationale behind the use of ethambutol in the standard tuberculosis treatment is to prevent the emergence of resistance to rifampicin in case of primary resistance to isoniazid. We evaluated whether early detection… read more here.
Keywords: isoniazid resistance; resistance; detection isoniazid; isoniazid ... See more keywords
Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action
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DOI: 10.1111/bph.14867
Abstract: The known mode of action of isoniazid (INH) is to inhibit bacterial cell wall synthesis following activation by the bacterial catalase–peroxidase enzyme KatG in Mycobacterium tuberculosis (Mtb). This simplistic model fails to explain (a) how… read more here.
Keywords: comprehensive mode; isoniazid; action isoniazid; novel comprehensive ... See more keywords
High Isoniazid Exposures When Administered with Rifapentine Once Weekly for Latent Tuberculosis in Individuals with Human Immunodeficiency Virus
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DOI: 10.1128/aac.01297-22
Abstract: Isoniazid pharmacokinetics are not yet well-described during once weekly, high-dose administrations with rifapentine (3HP) for latent tuberculosis infection (LTBI). Fewer data describe 3HP with dolutegravir-based antiretroviral therapy for the treatment of human immunodeficiency virus (HIV).… read more here.
Keywords: immunodeficiency virus; 3hp dolutegravir; isoniazid exposures; latent tuberculosis ... See more keywords