Quantification of pyrazinamide, isoniazid, acetyl-isoniazid and rifampicin by a high-performance liquid chromatography method in human plasma from patients with tuberculosis.
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DOI: 10.1002/jssc.202000672
Abstract: The aim of this study was to establish and validate an alternative high-performance liquid chromatography (HPLC) method for simultaneous quantification of pyrazinamide, isoniazid, acetyl-isoniazid and rifampicin in plasma of patients under treatment for tuberculosis. The… read more here.
Keywords: isoniazid acetyl; method; acetyl isoniazid; quantification ... See more keywords
Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid
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DOI: 10.1093/jac/dky378
Abstract: Objectives To describe the pharmacokinetics of isoniazid and acetyl-isoniazid in TB/HIV-coinfected patients, and assess the effects of efavirenz co-administration and a 50% increase in the dose of rifampicin on the pharmacokinetic parameters of isoniazid and… read more here.
Keywords: dose rifampicin; isoniazid; isoniazid acetyl; pharmacokinetics isoniazid ... See more keywords