Lipophilicity assessment of some isoniazid derivatives active against Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2020 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2020.124820
Abstract: Abstract Micelle-water partition coefficients, log Kp(NaDS/w), and octanol-water partition coefficients, log Po/w, for 9 isoniazid derivatives, previously assessed as active against Mycobacterium tuberculosis, were determined using derivative spectrophotometry and the shake flask method in buffer… read more here.
Keywords: lipophilicity; mycobacterium tuberculosis; active mycobacterium; isoniazid derivatives ... See more keywords
NEW ISONIAZID DERIVATIVES FOR ANTIMICROBIAL SPECTRUM EXTENSION AND HEPATOTOXICITY REDUCTION OF PARENT COMPOUND: IN VITRO AND IN VIVO ASSAYS
Sign Up to like & getrecommendations! Published in 2020 at "Farmacia"
DOI: 10.31925/farmacia.2020.3.20
Abstract: One of the most common adverse effects, in the case of medicines used voluntarily or not, of over dosage, or even of drugs administered in therapeutic doses, is hepatic injury, which is why, in the… read more here.
Keywords: new isoniazid; vivo; isoniazid derivatives; vitro ... See more keywords
In vitro Evaluation of Isoniazid Derivatives as Potential Agents Against Drug-Resistant Tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.868545
Abstract: The upsurge of multidrug-resistant tuberculosis has toughened the challenge to put an end to this epidemic by 2030. In 2020 the number of deaths attributed to tuberculosis increased as compared to 2019 and newly identified… read more here.
Keywords: evaluation isoniazid; tuberculosis; resistant tuberculosis; isoniazid derivatives ... See more keywords