Curcumin attenuates isoniazid‐induced hepatotoxicity by upregulating the SIRT1/PGC‐1α/NRF1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4288
Abstract: As a serious infectious disease, tuberculosis threatens global public health. Isoniazid is the first‐line drug not only in active tuberculosis but also in its prevention. Severe hepatotoxicity greatly limits its use. Curcumin, extracted from turmeric,… read more here.
Keywords: sirt1 pgc; isoniazid induced; curcumin; hepatotoxicity ... See more keywords
Characteristics of isoniazid-induced psychosis: a systematic review of case reports and case series
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DOI: 10.1007/s00228-024-03738-x
Abstract: Isoniazid, a first-line antitubercular drug, is associated with nervous system adverse drug reactions such as seizures, peripheral neuropathy, and psychosis. This systematic review of case reports and case series aimed to characterize the demographic, social,… read more here.
Keywords: isoniazid induced; case; case reports; induced psychosis ... See more keywords
SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2018.11.054
Abstract: Silent information regulator 1 (SIRT1) is a type III histone deacetylase that is related to the inhibition of the inflammatory response. The aim of this study was to investigate the regulation of SIRT1 on isoniazid-induced… read more here.
Keywords: sirt1; induced hepatocyte; hepatocyte injury; isoniazid induced ... See more keywords
Isoniazid-induced gynaecomastia: report of a paediatric case and review of literature
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DOI: 10.1186/s12902-020-00639-9
Abstract: Background Gynaecomastia is a fairly common condition in puberty but is rare in prepubertal boys. While it is necessary to exclude possible endocrinopathay in prepubertal gynaecomastia, medication is an important and potentially reversible cause to… read more here.
Keywords: paediatric case; case; report; gynaecomastia ... See more keywords
Influence of Ketogenic Diet and Phenytoin Sodium on Isoniazid Induced Epilepsy in Wistar Rats
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DOI: 10.5530/ijper.54.4.196
Abstract: Aim: The current research was set up to estimate the influence of ketogenic diet in combination with phenytoin sodium on isoniazid induced epilepsy in rats. Methods: In this work 30 rats were used with weight… read more here.
Keywords: ketogenic diet; isoniazid induced; induced epilepsy; phenytoin sodium ... See more keywords
Machine learning-enhanced confocal Raman imaging enables label-free diagnosis and spatial metabolic profiling of isoniazid-induced hepatotoxicity
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DOI: 10.7150/thno.119785
Abstract: Rationale: Isoniazid-induced liver injury (INH-ILI) poses a significant clinical challenge due to the lack of reliable, non-invasive, and real-time diagnostic tools. Here, we present an integrated platform that combines label-free confocal Raman spectroscopy imaging, machine… read more here.
Keywords: confocal raman; isoniazid induced; ili; machine ... See more keywords