Treatment With a Three-Drug Regimen for Pulmonary Tuberculosis Based on Rapid Molecular Detection of Isoniazid Resistance: A Noninferiority Randomized Trial (FAST-TB)
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DOI: 10.1093/ofid/ofac353
Abstract: Abstract Background The rationale behind the use of ethambutol in the standard tuberculosis treatment is to prevent the emergence of resistance to rifampicin in case of primary resistance to isoniazid. We evaluated whether early detection… read more here.
Keywords: isoniazid resistance; resistance; detection isoniazid; isoniazid ... See more keywords
The perceived impact of isoniazid resistance on outcome of first-line rifampicin-throughout regimens is largely due to missed rifampicin resistance
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DOI: 10.1371/journal.pone.0233500
Abstract: Background Meta-analyses on impact of isoniazid-resistant tuberculosis informed the World Health Organization recommendation of a levofloxacin-strengthened rifampicin-based regimen. We estimated the effect of initial rifampicin resistance (Rr) and/or isoniazid resistance (Hr) on treatment failure or… read more here.
Keywords: rifampicin; isoniazid resistance; tuberculosis; resistance ... See more keywords
Association Between the Phenotype and Genotype of Isoniazid Resistance Among Mycobacterium tuberculosis Isolates in Thailand
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DOI: 10.2147/idr.s242261
Abstract: Purpose The emergence of isoniazid-resistant tuberculosis (HR-TB) is a global public health problem, causing treatment failure and high mortality rates. This study aimed to determine the minimal inhibitory concentration (MIC) of isoniazid and detect the… read more here.
Keywords: isoniazid; isoniazid resistance; gene mutation; resistance ... See more keywords
Phenotypic low-level isoniazid resistance as a marker to predict ethionamide resistance in Mycobacterium tuberculosis
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DOI: 10.4103/ijmy.ijmy_34_17
Abstract: Background: Tuberculosis is one of the most prevalent diseases in Pakistan. Pakistan has the highest burden of MDR-TB in the Eastern Mediterranean region. Ethionamide is an anti-tuberculous drug frequently used to treat MDR-TB. Its drug… read more here.
Keywords: isoniazid; isoniazid resistance; ethionamide resistance; resistance ... See more keywords