Quantification of pyrazinamide, isoniazid, acetyl-isoniazid and rifampicin by a high-performance liquid chromatography method in human plasma from patients with tuberculosis.
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DOI: 10.1002/jssc.202000672
Abstract: The aim of this study was to establish and validate an alternative high-performance liquid chromatography (HPLC) method for simultaneous quantification of pyrazinamide, isoniazid, acetyl-isoniazid and rifampicin in plasma of patients under treatment for tuberculosis. The… read more here.
Keywords: isoniazid acetyl; method; acetyl isoniazid; quantification ... See more keywords
Can phenotypic data complement our understanding of antimycobacterial effects for drug combinations?
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DOI: 10.1093/jac/dkz369
Abstract: Abstract Objectives To demonstrate how phenotypic cell viability data can provide insight into antimycobacterial effects for the isoniazid/rifampicin treatment backbone. Methods Data from a Mycobacterium komossense hollow-fibre infection model comprising a growth control group, rifampicin… read more here.
Keywords: rifampicin; antimycobacterial effects; cell; phenotypic cell ... See more keywords
Optimization of dosing regimens of isoniazid and rifampicin in children with tuberculosis in India
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DOI: 10.1111/bcp.13846
Abstract: Pharmacokinetic studies in the past have shown inadequate antituberculosis drug levels in children with the currently available dosing regimens. This study attempted to investigate the pharmacokinetics of isoniazid and rifampicin, when used in children, and… read more here.
Keywords: regimens isoniazid; dosing regimens; children tuberculosis; rifampicin children ... See more keywords
Pharmacokinetics and safety/tolerability of isoniazid, rifampicin and pyrazinamide in children and adolescents treated for tuberculous meningitis
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DOI: 10.1136/archdischild-2020-321426
Abstract: Objective To assess the pharmacokinetics and safety/tolerability of isoniazid, rifampicin and pyrazinamide in children and adolescents with tuberculous meningitis (TBM). Design Prospective observational pharmacokinetic study with an exploratory pharmacokinetic/pharmacodynamic analysis. Setting Hasan Sadikin Hospital, Bandung,… read more here.
Keywords: rifampicin pyrazinamide; treatment; children adolescents; isoniazid rifampicin ... See more keywords
Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report
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DOI: 10.1186/s13104-017-2678-6
Abstract: BackgroundFixed drug combination of isoniazid and rifampicin is a rare cause of poisoning even in endemic countries for tuberculosis infection. Severe poisoning can cause severe morbidity and mortality if not treated promptly. Though intravenous pyridoxine… read more here.
Keywords: pyridoxine; combination; isoniazid; severe poisoning ... See more keywords
Stability Study of Isoniazid and Rifampicin Oral Solutions Using Hydroxypropyl-Β-Cyclodextrin to Treat Tuberculosis in Paediatrics
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DOI: 10.3390/pharmaceutics12020195
Abstract: (1) Background: First-line antituberculosis treatment in paediatrics entails the administration of Isoniazid, Pyrazinamide, and Rifampicin. This study examines the possibility of developing a combined dose liquid formulation for oral use that would facilitate dose adjustment… read more here.
Keywords: study isoniazid; hydroxypropyl cyclodextrin; stability study; stability ... See more keywords
Hepatoprotective Activity of Yigan Mingmu Oral Liquid against Isoniazid/Rifampicin-Induced Liver Injuries in Rats
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DOI: 10.4236/cm.2018.94010
Abstract: Background: To explore the hepatoprotective effect of Yigan mingmu oral liquid (YGMM) on isoniazid-rifampicin induced liver injury in rats. Methods: Total 38 SD rats were randomly divided into 6 groups including control group, model group,… read more here.
Keywords: induced liver; rifampicin induced; group; isoniazid rifampicin ... See more keywords