Radical Alkylcyanation of 1,6-Enynes with Isonitriles as Bifunctional Reagents.
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DOI: 10.1021/acs.orglett.4c03744
Abstract: We report a radical cyano-cyclization of 1,6-enynes with isonitriles via photochemically driven nickel catalysis, forging alkenyl nitrile-tethered γ-lactams under mild conditions. This reaction leverages the photoexcitation of in situ generated nickel (isonitrile) species to facilitate… read more here.
Keywords: bifunctional reagents; alkylcyanation enynes; enynes isonitriles; isonitriles bifunctional ... See more keywords