Inhibition of the Yersinia pestis Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis by α-Phenyl-Substituted Reverse Fosmidomycin Analogues
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.9b04171
Abstract: Fosmidomycin inhibits IspC (1-deoxy-d-xylulose 5-phosphate reductoisomerase), the first committed enzyme in the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis. The MEP pathway of isoprenoid biosynthesis is essential to the causative agent of the plague, Yersinia… read more here.
Keywords: isoprenoid biosynthesis; pestis; pathway isoprenoid; phosphate ... See more keywords
Shortcut for isoprenoid biosynthesis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Catalysis"
DOI: 10.1038/s41929-019-0240-8
Abstract: Isoprenoids are a diverse class of natural products which find application in many industries, for example as drugs and fragrances. Their biosynthesis involves the use of dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) as central… read more here.
Keywords: isoprenoid biosynthesis; dmapp ipp; biosynthesis; pathway ... See more keywords
Downregulation of Squalene Synthase Broadly Impacts Isoprenoid Biosynthesis in Guayule
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12040303
Abstract: Production of natural rubber by Parthenium argentaum (guayule) requires increased yield for economic sustainability. An RNAi gene silencing strategy was used to engineer isoprenoid biosynthesis by downregulation of squalene synthase (SQS), such that the pool… read more here.
Keywords: isoprenoid biosynthesis; production; squalene synthase; guayule ... See more keywords