In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105528
Abstract: Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthetic pathway (IBP), produces the isoprenoid (geranylgeranyl pyrophosphate, GGPP) used in protein geranylgeranylation reactions. Our prior studies utilizing triazole bisphosphonate-based GGDPS inhibitors (GGSIs) have revealed that… read more here.
Keywords: combination; protein geranylgeranylation; isoprenoid biosynthetic; therapy ... See more keywords
Flavescence Dorée-Derived Leaf Yellowing in Grapevine (Vitis vinifera L.) Is Associated to a General Repression of Isoprenoid Biosynthetic Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.00896
Abstract: Flavescence dorée (FD), caused by the phytoplasma Candidatus Phytoplasma vitis, is a major threat to vineyard survival in different European grape-growing areas. It has been recorded in French vineyards since the mid-1950s, and rapidly spread… read more here.
Keywords: infection; repression; biosynthetic pathways; isoprenoid biosynthetic ... See more keywords
Targeting the Isoprenoid Biosynthetic Pathway in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010111
Abstract: Multiple myeloma (MM) is a plasma cell malignancy for which there is currently no cure. While treatment options for MM have expanded over the last two decades, all patients will eventually become resistant to current… read more here.
Keywords: biosynthetic pathway; multiple myeloma; isoprenoid biosynthetic; ibp inhibitors ... See more keywords