Titanium isopropoxide-mediated cis-selective synthesis of 3,4-substituted butyrolactones from CO2.
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DOI: 10.1039/d2cc00446a
Abstract: We report a Ti(OiPr)4-mediated multicomponent reaction, which produces 3,4-substituted cis-δ-lactones from alkyl magnesium chloride, benzaldehyde and CO2. The key intermediate, titanacyclopropane, is formed in situ from Ti(OiPr)4 and a Grignard reagent, which enables 1,2-dinucleophilic reactivity… read more here.
Keywords: selective synthesis; synthesis substituted; mediated cis; isopropoxide mediated ... See more keywords