Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2118400
Abstract: Abstract Isopropoxy benzene guanidine (IBG) is a novel substituted benzene guanidine analogue with antibacterial activity against multidrug-resistant bacteria. However, the bioavailability of IBG is not optimal due to its finite aqueous solubility, thus hampering its… read more here.
Keywords: isopropoxy benzene; guanidine; bioavailability; benzene guanidine ... See more keywords
Mechanism of Action of Isopropoxy Benzene Guanidine against Multidrug-Resistant Pathogens
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DOI: 10.1128/spectrum.03469-22
Abstract: As antibiotic discovery stagnates, the world is facing a growing menace from the emergence of bacteria that are resistant to almost all available antibiotics. The key to winning this race is to explore distinctive mechanisms… read more here.
Keywords: colistin; isopropoxy benzene; benzene guanidine; multidrug resistant ... See more keywords
Isopropoxy Benzene Guanidine Ameliorates Streptococcus suis Infection In Vivo and In Vitro
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DOI: 10.3390/ijms24087354
Abstract: Streptococcus suis, an encapsulated zoonotic pathogen, has been reported to cause a variety of infectious diseases, such as meningitis and streptococcal-toxic-shock-like syndrome. Increasing antimicrobial resistance has triggered the need for new treatments. In the present… read more here.
Keywords: isopropoxy benzene; infection vivo; vivo vitro; suis infection ... See more keywords