Transcriptomics and metabolomics reveal the role of CYP1A2 in psoralen/isopsoralen‐induced metabolic activation and hepatotoxicity
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DOI: 10.1002/ptr.7604
Abstract: Psoralen and isopsoralen are the pharmacologically important but hepatotoxic components in Psoraleae Fructus. The purpose of this study was to reveal the underlying mechanism of psoralen/isopsoralen‐induced hepatotoxicity. Initially, we applied integrated analyses of transcriptomic and… read more here.
Keywords: isopsoralen induced; psoralen isopsoralen; role cyp1a2; metabolic activation ... See more keywords
The changes of hepatic bile acid synthesis and transport and bile acids profiles in isopsoralen-induced liver injury C57BL/6J mice
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DOI: 10.1080/13880209.2022.2116057
Abstract: Abstract Contest Isopsoralen, one of the main active and quality-control compounds in Psoralea corylifolia L. (Fabaceae), has antitumor and oestrogen-like effects. Previous studies demonstrated that isopsoralen induced hepatotoxicity and its long-term exposure led to cholestatic… read more here.
Keywords: isopsoralen induced; day; liver injury; seven day ... See more keywords