Synthetic transformations of isoquinoline alkaloids: 1-(N-alkyl-1,2,3-triazol-4-yl)-6,18-endo-ethenodihydrothebainehydroquinones and triazolylnaphthohydroquinone-containing benzofuroazocines from thebaine
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-017-2145-2
Abstract: 1-Ethynyl-6,18-endo-ethenodihydrothebainehydroquinone reacted with azides in the presence of CuSO4·5H2O and sodium ascorbate in DMF, forming the respective 1-(N-alkyl(arylalkyl)triazol-4-yl)-6,18-endo-ethenodihydrothebainehydroquinones, which underwent retrodiene cleavage upon heating in DMF, forming functionalized tetrahydrofuro[4,3,2-fg][3]benzazocines containing naphthohydroquinone and 1,2,3-triazolyl substituents. read more here.
Keywords: transformations isoquinoline; endo ethenodihydrothebainehydroquinones; isoquinoline alkaloids; synthetic transformations ... See more keywords
Isoquinoline alkaloids from three Madagascan Crinum (Amaryllidaceae) species.
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DOI: 10.1016/j.bse.2017.12.008
Abstract: The phytochemistry of two Madagascan Crinum species, Crinum hardyi Lehmiller and Crinum pronkii Lehmiller were investigated and compared to that of Crinum firmifolium Baker which has been investigated previously. In addition to hippadine, lycorine, hippeastrine,… read more here.
Keywords: crinum; alkaloids three; madagascan crinum; three madagascan ... See more keywords
Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine.
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DOI: 10.1016/j.ejmech.2021.113839
Abstract: Alkaloids are one of the most important classes of plant bioactives. Among these isoquinoline alkaloids possess varied structures and exhibit numerous biological activities. Basically these are biosynthetically produced via phenylpropanoid pathway. However, occasionally some mixed… read more here.
Keywords: plant; chemistry; isoquinoline alkaloids; biology ... See more keywords
Establishing the metabolic network of isoquinoline alkaloids from the Macleaya genus.
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DOI: 10.1016/j.phytochem.2021.112696
Abstract: Metabolic networks can provide insight into the biosynthesis pathways of natural products present in plant-derived medicines. Here, we primarily established a highly efficient and targeted method for the systematic screening of isoquinoline alkaloids from the… read more here.
Keywords: macleaya genus; isoquinoline alkaloids; metabolic network; alkaloids macleaya ... See more keywords
Mucroniferanines A-G, Isoquinoline Alkaloids from Corydalis mucronifera.
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DOI: 10.1021/acs.jnatprod.7b00847
Abstract: Five pairs of isoquinoline alkaloid enantiomers, mucroniferanines A-E (1-5), two inseparable epimeric pairs, mucroniferanines F and G (6, 7), and 10 known isoquinoline alkaloids (8-17) were obtained from Corydalis mucronifera. The structures were characterized using… read more here.
Keywords: alkaloids corydalis; mucroniferanines isoquinoline; isoquinoline alkaloids; corydalis mucronifera ... See more keywords
Baicalensines A and B, Two Isoquinoline Alkaloids from the Roots of Thalictrum baicalense.
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DOI: 10.1021/acs.orglett.0c02444
Abstract: Baicalensines A (1) and B (2) were isolated from the roots of Thalictrum baicalense and structurally characterized using spectroscopic data, 13C NMR calculations, and the CASE algorithm. Compound 1, representing a new class of alkaloid… read more here.
Keywords: alkaloids roots; two isoquinoline; thalictrum baicalense; baicalensines two ... See more keywords
Enantioselective synthesis of naturally occurring isoquinoline alkaloids: (S)-(−)-trolline and (R)-(+)-oleracein E
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00062f
Abstract: The highly efficient asymmetric syntheses of a pair of enantiomers, (S)-(−)-trolline and (R)-(+)-oleracein E, from commercially available 2-methyl-3-butyn-2-ol, benzaldehyde and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline have been achieved in five steps with the catalytic enantioselective C1-alkynylation of 6,7-dimethoxy-3,4-dihydroisoquinoline as… read more here.
Keywords: trolline oleracein; isoquinoline alkaloids; naturally occurring; occurring isoquinoline ... See more keywords
Effects of isoquinoline alkaloids on apparent ileal digestibility of amino acids, acid hydrolyzed ether extract, and starch by young growing pigs fed corn-soybean meal diets
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DOI: 10.1093/tas/txaa054
Abstract: Abstract An experiment was conducted to test the hypothesis that a preparation of isoquinoline alkaloids (IQ) obtained from Macleaya cordata and added to corn-soybean meal diets increases the apparent ileal digestibility (AID) of amino acids… read more here.
Keywords: corn soybean; period; isoquinoline alkaloids; aid ... See more keywords
Cytokine storm-calming property of the isoquinoline alkaloids in Coptis chinensis Franch
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.973587
Abstract: Coronavirus disease (COVID-19) has spread worldwide and its effects have been more devastating than any other infectious disease. Importantly, patients with severe COVID-19 show conspicuous increases in cytokines, including interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1,… read more here.
Keywords: alkaloids coptis; coptis chinensis; chinensis franch; isoquinoline alkaloids ... See more keywords
Isoquinoline Alkaloids as Protein Tyrosine Phosphatase Inhibitors from a Deep-Sea-Derived Fungus Aspergillus puniceus
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DOI: 10.3390/md20010078
Abstract: Puniceusines A–N (1–14), 14 new isoquinoline alkaloids, were isolated from the extracts of a deep-sea-derived fungus, Aspergillus puniceus SCSIO z021. Their structures were elucidated by spectroscopic analyses. The absolute configuration of 9 was determined by… read more here.
Keywords: fungus aspergillus; deep sea; isoquinoline alkaloids; derived fungus ... See more keywords
Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids
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DOI: 10.3390/molecules27092815
Abstract: The Chelidonium majus plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they… read more here.
Keywords: chelidonium majus; extraction chelidonium; vnadess; extraction ... See more keywords