Novel synthesis of biologically active indolo [3,2-C] isoquinoline derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2014.07.009
Abstract: Abstract Indole-2-carboxylates are refluxed with hydrazine hydrate to form 5-substituted-3-phenylindole-2-carboxyhydrazides. These are again converted to corresponding indole-2-carboxyazides. Azides are further converted into carbamates and finally these carbamates are cyclized to form the respective substituted 6H,… read more here.
Keywords: active indolo; synthesis biologically; indolo isoquinoline; isoquinoline derivatives ... See more keywords
K 3 PO 4 promoted dipolar [3+3] cyclization: Direct synthesis of pyrazino[2,1- a ]isoquinoline derivatives
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DOI: 10.1016/j.tetlet.2017.12.011
Abstract: Abstract A K 3 PO 4 promoted dipolar [3+3] cyclization of dihydroisoquinoline imines and arylacyl bromides has been developed. This process realized the direct synthesis of pyrazino[2,1- a ]isoquinoline derivatives in 44–69% yields. A head… read more here.
Keywords: dipolar cyclization; direct synthesis; synthesis pyrazino; isoquinoline derivatives ... See more keywords
I2-DMSO-Mediated N-H/α-C(sp3)-H Difunctionalization of Tetrahydroisoquinoline: Formal [2 + 2 + 1] Annulation for the Construction of Pyrrolo[2,1-a]isoquinoline Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00813
Abstract: An I2-DMSO-mediated cascade reaction using methyl ketones and 1,2,3,4-tetrahydroisoquinolines (THIQs) as commercially available substrates has been developed for the construction of pyrrolo[2,1-a]isoquinoline derivatives. This metal-free process involves N-H/α-C(sp3)-H difunctionalization of THIQ. Two C-C bonds and… read more here.
Keywords: construction pyrrolo; dmso mediated; pyrrolo isoquinoline; sp3 difunctionalization ... See more keywords
Highly Enantioselective Synthesis of [1,2,4]Triazino[5,4-a]isoquinoline Derivatives via (3 + 3) Cycloaddition Reactions of Diazo Compounds and Isoquinolinium Methylides.
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DOI: 10.1021/acs.orglett.2c01122
Abstract: An array of chiral [1,2,4]triazino[5,4-a]isoquinoline derivatives were obtained in excellent yields (up to 98%) and with excellent enantioselectivities (up to 99% ee) via a new highly asymmetric (3 + 3) cycloaddition reaction of diazo compounds… read more here.
Keywords: diazo compounds; isoquinolinium methylides; isoquinoline derivatives; triazino isoquinoline ... See more keywords
Rhodium(iii) complexes with isoquinoline derivatives as potential anticancer agents: in vitro and in vivo activity studies.
Sign Up to like & getrecommendations! Published in 2019 at "Dalton transactions"
DOI: 10.1039/c9dt01951k
Abstract: Two rhodium complexes Rh1 and Rh2 with isoquinoline derivatives were synthesized and characterized. Both complexes displayed strong anticancer activity against various cancer cells and low cytotoxicity against non-cancer cells. These complexes triggered apoptosis via mitochondrial… read more here.
Keywords: rh1 rh2; anticancer agents; isoquinoline derivatives; anticancer ... See more keywords
Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s137608
Abstract: Objective To discover novel isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins (IAP) for the treatment of ovarian cancer. Methods We first synthesized 533 isoquinoline derivatives, and screened them using CCK-8 to measure their… read more here.
Keywords: apoptosis; derivatives inhibition; treatment; ovarian cancer ... See more keywords