Highly Enantioselective Synthesis of [1,2,4]Triazino[5,4-a]isoquinoline Derivatives via (3 + 3) Cycloaddition Reactions of Diazo Compounds and Isoquinolinium Methylides.
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DOI: 10.1021/acs.orglett.2c01122
Abstract: An array of chiral [1,2,4]triazino[5,4-a]isoquinoline derivatives were obtained in excellent yields (up to 98%) and with excellent enantioselectivities (up to 99% ee) via a new highly asymmetric (3 + 3) cycloaddition reaction of diazo compounds… read more here.
Keywords: diazo compounds; isoquinolinium methylides; isoquinoline derivatives; triazino isoquinoline ... See more keywords