Construction of Peptide-Isoquinolone Conjugates via Rh(III)-Catalyzed C-H Activation/Annulation.
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DOI: 10.1021/acs.orglett.3c00766
Abstract: Herein, we disclose a Rh(III)-catalyzed C-H activation/annulation reaction for the derivatization of Lys-based peptides, in situ affording diverse peptide-isoquinolone conjugates. This approach features racemization-free conditions, high atom- and step-economy, excellent chemo- and site-selectivity, and broad… read more here.
Keywords: isoquinolone; peptide isoquinolone; catalyzed activation; isoquinolone conjugates ... See more keywords