Construction of Peptide-Isoquinolone Conjugates via Rh(III)-Catalyzed C-H Activation/Annulation.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00766
Abstract: Herein, we disclose a Rh(III)-catalyzed C-H activation/annulation reaction for the derivatization of Lys-based peptides, in situ affording diverse peptide-isoquinolone conjugates. This approach features racemization-free conditions, high atom- and step-economy, excellent chemo- and site-selectivity, and broad… read more here.
Keywords: isoquinolone; peptide isoquinolone; catalyzed activation; isoquinolone conjugates ... See more keywords
Design, synthesis, and mechanism study of novel natural-based isoquinolone derivatives as potential antifungal agents.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2025.2492353
Abstract: Abstract A series of isoquinolone compounds Ia-Iq containing amide moiety were rationally designed and synthesized based-on isoquinolone alkaloids. Their structures were confirmed by 1H NMR,13C NMR and HRMS. Most of the title compounds showed medium… read more here.
Keywords: based isoquinolone; isoquinolone; study novel; mechanism study ... See more keywords