Potential antiviral activity of isorhamnetin against SARS‐CoV‐2 spike pseudotyped virus in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Drug Development Research"
DOI: 10.1002/ddr.21815
Abstract: Abstract Coronavirus Disease 2019 (COVID‐19) cases and deaths are still rising worldwide, there is currently no effective treatment for severe inflammation and acute lung injury caused by new coronavirus (SARS‐COV‐2) infection. Therapies to prevent or… read more here.
Keywords: spike pseudotyped; pseudotyped virus; cov spike; drug ... See more keywords
Anti-hyperuricemic effect of isorhamnetin in cultured hepatocytes and model mice: structure–activity relationships of methylquercetins as inhibitors of uric acid production
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DOI: 10.1007/s10616-018-0275-8
Abstract: Hyperuricemia is an important risk factor for gout. Isorhamnetin (3′-O-methylquercetin) is an O-methylated flavonol, which occurs in onion, almond and sea buckthorn. It is also one of the metabolites of quercetin in mammals. In the… read more here.
Keywords: hyperuricemic effect; production; anti hyperuricemic; activity ... See more keywords
Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.05.009
Abstract: To unveil the possible protective role of isorhamnetin, an immediate 3'-O-methylated metabolite of quercetin, in cardiomyocyte under hypoxia/reoxygenation (H/R) condition and the underlying mechanisms involved, H9c2 cardiomyocytes were exposed to the vehicle or H/R for… read more here.
Keywords: h9c2 cardiomyocytes; induced injure; isorhamnetin; apoptosis ... See more keywords
Extraction of isorhamnetin conjugates from Opuntia ficus-indica (L.) Mill using supercritical fluids
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Supercritical Fluids"
DOI: 10.1016/j.supflu.2016.09.003
Abstract: Abstract Flavonoids from Opuntia ficus-indica (L.) Mill were extracted using supercritical carbon dioxide (SC-CO 2 ) technique. A central composite design was used to evaluate the influence of pressure, temperature and flow rate on the… read more here.
Keywords: extraction; ficus indica; indica mill; opuntia ficus ... See more keywords
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20220319
Abstract: Isorhamnetin, a natural flavonoid, has strong antioxidant and antifibrotic effects, and a regulatory effect against Ca2+-handling. Atrial remodeling due to fibrosis and abnormal intracellular Ca2+ activities contributes to initiation and persistence of atrial fibrillation (AF).… read more here.
Keywords: isorhamnetin; atrial fibrillation; angii induced; effect isorhamnetin ... See more keywords
Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-κB/Nrf2.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1792-2678
Abstract: Acetaminophen (APAP)-induced acute liver injury (ALI) is the principal cause of acute liver failure (ALF) in some countries including the United States and with few available treatments. Isorhamnetin is a bioflavonoid that is found in… read more here.
Keywords: acetaminophen induced; stress inflammation; acetaminophen; oxidative stress ... See more keywords
Isorhamnetin Induces Apoptosis and Suppresses Metastasis of Human Endometrial Carcinoma Ishikawa Cells via Endoplasmic Reticulum Stress Promotion and Matrix Metalloproteinase-2/9 Inhibition In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11213415
Abstract: Endometrial cancer (EC) is a very common female cancer which has attracted more and more attention. According to the individual patient’s condition, the current treatment of EC patients is mainly based on surgery, which is… read more here.
Keywords: endoplasmic reticulum; vitro vivo; ishikawa cells; reticulum stress ... See more keywords
Isorhamnetin Reduces Glucose Level, Inflammation, and Oxidative Stress in High-Fat Diet/Streptozotocin Diabetic Mice Model
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020502
Abstract: Background: Isorhamnetin is a flavonoid that is found in medical plants. Several studies showed that isorhamnetin has anti-inflammatory and anti-obesity effects. This study aims to investigate the anti-diabetic effects of isorhamnetin in a high-fat diet… read more here.
Keywords: compared vehicle; diabetic mice; isorhamnetin; model ... See more keywords