Isosteviol Sodium Protects against Ischemic Stroke by Modulating Microglia/Macrophage Polarization via Disruption of GAS5/miR-146a-5p sponge
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DOI: 10.1038/s41598-019-48759-0
Abstract: Recent studies have shown that transforming microglia phenotype from pro-inflammation of M1 phenotype to anti-inflammation and tissue-repairing M2 phenotype may be an effective therapeutic strategy for preventing ischemic stroke brain injury. Isosteviol Sodium (STV-Na) has… read more here.
Keywords: ischemic stroke; isosteviol sodium; mir 146a; gas5 ... See more keywords
Isosteviol sodium injection improves outcomes by modulating TLRs/NF-κB-dependent inflammatory responses following experimental traumatic brain injury in rats
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DOI: 10.1097/wnr.0000000000001033
Abstract: Previous studies have shown that isosteviol sodium (STVNa) protects against permanent cerebral ischemia injury by inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-&kgr;B)-mediated inflammatory responses. Overwhelming evidence shows that toll-like receptors (TLRs)… read more here.
Keywords: inflammatory responses; traumatic brain; isosteviol sodium; brain injury ... See more keywords
Isosteviol sodium protects heart embryonic H9c2 cells against oxidative stress by activating Akt/GSK-3β signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Die Pharmazie"
DOI: 10.1691/ph.2020.9851
Abstract: Oxidative stress plays a crucial role in pathogenesis of various cardiovascular diseases. Recent studies reported that isosteviol sodium (STVNa) harbor cardioprotective properties. Here, we explore the potential cardioprotective effect of STVNa on H₂ O₂ -induced… read more here.
Keywords: isosteviol sodium; heart embryonic; stress; akt gsk ... See more keywords
Isosteviol Sodium (STVNA) Reduces Pro-Inflammatory Cytokine IL-6 and GM-CSF in an In Vitro Murine Stroke Model of the Blood–Brain Barrier (BBB)
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14091753
Abstract: Early treatment with glucocorticoids could help reduce both cytotoxic and vasogenic edema, leading to improved clinical outcome after stroke. In our previous study, isosteviol sodium (STVNA) demonstrated neuroprotective effects in an in vitro stroke model,… read more here.
Keywords: stvna; isosteviol sodium; sodium stvna; blood brain ... See more keywords