Structural and mechanistic insights into modified G-quadruplex thrombin-binding DNA aptamers.
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DOI: 10.1016/j.bbrc.2019.04.025
Abstract: Thrombin-binding aptamer (TBA) can fold into a G-quadruplex structure necessary for interacting with thrombin. When one thymidine residue of the TGT loop at position 7 is replaced with unlocked uracil (UNA), d-isothymidine (D-isoT) or l-isothymidine… read more here.
Keywords: structural mechanistic; isot una; thrombin; insights modified ... See more keywords