Ignoring the elephant in the room—overregulated isotretinoin and unregulated dietary supplements in the United States
Sign Up to like & getrecommendations! Published in 2022 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2022.2111643
Abstract: Abstract Isotretinoin is an acne medication regulated by the Food and Drug Administration (FDA) iPledge Risk Evaluation and Mitigation Strategy program due to its potential for birth defects. This program enforces monthly pregnancy tests and… read more here.
Keywords: isotretinoin; ignoring elephant; room overregulated; dietary supplements ... See more keywords
An evaluation of peripapillar choroidal thickness in patients receiving systemic isotretinoin treatment
Sign Up to like & getrecommendations! Published in 2019 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2018.1503289
Abstract: Abstract Purpose: Oral isotretinoin (13-cis retinoic acid, 13-cis RA) was approved for severe acne treatment by the FDA in 1982. The ocular side effects associated with oral isotretinoin use are mostly dose-dependent. Numerous ocular pathologies… read more here.
Keywords: choroidal; patients receiving; isotretinoin treatment; isotretinoin ... See more keywords
Investigation of systemic immune-inflammation index and systemic inflammation response index as an indicator of the anti-inflammatuary effect of isotretinoin in patients with acne vulgaris
Sign Up to like & getrecommendations! Published in 2022 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2022.2081700
Abstract: Abstract Purpose Oral isotretinoin (ISO) can effect markers of inflammation in patients with acne vulgaris. Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) were described as novel inflammatory and prognostic biomarkers. The present… read more here.
Keywords: acne vulgaris; inflammation; index; isotretinoin ... See more keywords
Co-delivery of isotretinoin and clindamycin by phospholipid-based mixed micellar system confers synergistic effect for treatment of acne vulgaris
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2021.1919618
Abstract: Abstract Background The combination therapy of Isotretinoin (ITR) and antibacterial formulations administered through topical route suffer from several limitations including reduced therapeutic efficacy and low patient-compliance. Experiment The present study aimed to develop biocompatible lipid-based… read more here.
Keywords: based mixed; delivery; efficacy; clindamycin ... See more keywords
Bioanalysis of Endogenous Isotretinoin in Altered and Unaltered Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Electrospray Ionization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac102
Abstract: Bioanalytical method development and validation of endogenous Isotretinoin with Isotretinoin D5 as internal standard was done as per current regulatory guidelines. The method is simple, rugged and sensitive enough to estimate endogenous Isotretinoin using the… read more here.
Keywords: chromatography tandem; tandem mass; isotretinoin; mass spectrometry ... See more keywords
The unknown silent drug reaction in acne patients: rare case of isotretinoin-induced haematuria
Sign Up to like & getrecommendations! Published in 2023 at "Family Practice"
DOI: 10.1093/fampra/cmad043
Abstract: Acne vulgaris is one of the most frequent visits to primary care physicians and dermatologists alike. Isotretinoin is the backbone of acne treatment. In most countries, depending on the health care system, isotretinoin is prescribed… read more here.
Keywords: isotretinoin; care physicians; nephrology; case ... See more keywords
Safety of Combined Fractional Microneedle Radiofrequency and CO2 as an Early Intervention for Inflammatory Acne and Scarring Treated With Concomitant Isotretinoin.
Sign Up to like & getrecommendations! Published in 2020 at "Dermatologic Surgery"
DOI: 10.1097/dss.0000000000002364
Abstract: BACKGROUND Fractional microneedle radiofrequency (FMRF) systems are popular options for treating acne scars. However, treatment efficacy when used in combination with traditional ablative fractional laser (AFL) and the safety profile with concomitant use of isotretinoin… read more here.
Keywords: isotretinoin; combination; treatment; inflammatory acne ... See more keywords
First use of the Adolescent Depression Rating Scale (ADRS) in the management of young people with severe acne treated with isotretinoin: a pilot study of an active monitoring of depressive disorders by dermatologists
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.15039
Abstract: During isotretinoin treatment, special attention is required to detect any symptom or change in the mental health of patients. The monitoring is complex for adolescents because of confounding factors such as mood changes associated with… read more here.
Keywords: depression rating; use adolescent; first use; rating scale ... See more keywords
Alopecia areata and isotretinoin; coincidence or causal relation
Sign Up to like & getrecommendations! Published in 2020 at "Dermatologic Therapy"
DOI: 10.1111/dth.13280
Abstract: Isotretinoin is a safe and useful medication for acne management. Adverse effects are mostly related to cutaneous and mucous membranes. We present a case of a 24‐year‐old female patient who was on treatment with isotretinoin… read more here.
Keywords: alopecia areata; coincidence causal; areata isotretinoin; causal relation ... See more keywords
The effect of isotretinoin therapy on oxidative damage in rats
Sign Up to like & getrecommendations! Published in 2020 at "Dermatologic Therapy"
DOI: 10.1111/dth.14111
Abstract: Isotretinoin is prescribed in many dermatologic disorders, but mostly in acne. There is limited research about oxidative stress induced by isotretinoin and its effects on the liver tissue, muscle tissue, and blood. In this study,… read more here.
Keywords: oxidative damage; treatment; isotretinoin; therapy ... See more keywords
Apremilast: A novel adjuvant treatment for refractory isotretinoin‐induced acne fulminans
Sign Up to like & getrecommendations! Published in 2022 at "Dermatologic Therapy"
DOI: 10.1111/dth.15637
Abstract: Acne fulminans (AF) is a severe form of inflammatory acne, character-ized by an abrupt explosive flare of multiple ulceronecrotic lesions, which can be associated with systemic symptoms. 1 We report the first case of therapy-refractory… read more here.
Keywords: novel adjuvant; refractory; isotretinoin; apremilast novel ... See more keywords