Cytotoxic alkaloids from Pogonopus tubulosus: G2/M cell cycle arrest and inhibition of DNA topoisomerase IIα by isotubulosine
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DOI: 10.1002/ptr.6059
Abstract: Phytochemical investigation of Pogonopus tubulosus trunk led to the isolation of isotubulosine and alangiside, tetrahydroisoquinoline indolic monoterpene alkaloids reported here for the first time for the family Rubiaceae and the genus Pogonopus, respectively. Isotubulosine proved… read more here.
Keywords: dna topoisomerase; arrest; isotubulosine; pogonopus tubulosus ... See more keywords