Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity
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DOI: 10.1016/j.ccell.2020.04.013
Abstract: Summary Anti-CD40 monoclonal antibodies (mAbs) comprise agonists and antagonists, which display promising therapeutic activities in cancer and autoimmunity, respectively. We previously showed that epitope and isotype interact to deliver optimal agonistic anti-CD40 mAbs. The impact… read more here.
Keywords: antitumor activity; isotype; isotype switching; anti cd40 ... See more keywords
Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol
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DOI: 10.1080/07391102.2016.1271749
Abstract: Beta-sitosterol (β-SITO), a phytosterol present in many edible vegetables, has been reported to possess antineoplastic properties and cancer treatment potential. We have shown previously that it binds at a unique site (the ‘SITO-site’) compared to… read more here.
Keywords: isotype; elucidation anticancer; sito; potential tubulin ... See more keywords
The anti-carbamylated protein antibody response is of overall low avidity despite extensive isotype switching
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DOI: 10.1093/rheumatology/key135
Abstract: Objective To better understand the contribution of autoantibodies in RA and the biology of their responses, we evaluated the avidity of the anti-carbamylated protein (anti-CarP) antibody response. Methods The avidity of anti-CarP antibody, ACPA and… read more here.
Keywords: isotype; avidity; response; avidity anti ... See more keywords
Fremanezumab and its isotype slow propagation rate and shorten cortical recovery period but do not prevent occurrence of cortical spreading depression in rats with compromised blood brain barrier.
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DOI: 10.1097/j.pain.0000000000001791
Abstract: Most centrally-acting migraine preventive drugs suppress frequency and velocity of cortical spreading depression (CSD). The purpose of the current study was to determine how the new class of peripherally acting migraine preventive drug (i.e., the… read more here.
Keywords: propagation; depression; isotype; period ... See more keywords