Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity
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DOI: 10.1016/j.ccell.2020.04.013
Abstract: Summary Anti-CD40 monoclonal antibodies (mAbs) comprise agonists and antagonists, which display promising therapeutic activities in cancer and autoimmunity, respectively. We previously showed that epitope and isotype interact to deliver optimal agonistic anti-CD40 mAbs. The impact… read more here.
Keywords: antitumor activity; isotype; isotype switching; anti cd40 ... See more keywords
Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol
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DOI: 10.1080/07391102.2016.1271749
Abstract: Beta-sitosterol (β-SITO), a phytosterol present in many edible vegetables, has been reported to possess antineoplastic properties and cancer treatment potential. We have shown previously that it binds at a unique site (the ‘SITO-site’) compared to… read more here.
Keywords: isotype; elucidation anticancer; sito; potential tubulin ... See more keywords
The anti-carbamylated protein antibody response is of overall low avidity despite extensive isotype switching
Sign Up to like & getrecommendations! Published in 2018 at "Rheumatology"
DOI: 10.1093/rheumatology/key135
Abstract: Objective To better understand the contribution of autoantibodies in RA and the biology of their responses, we evaluated the avidity of the anti-carbamylated protein (anti-CarP) antibody response. Methods The avidity of anti-CarP antibody, ACPA and… read more here.
Keywords: isotype; avidity; response; avidity anti ... See more keywords
Fremanezumab and its isotype slow propagation rate and shorten cortical recovery period but do not prevent occurrence of cortical spreading depression in rats with compromised blood brain barrier.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001791
Abstract: Most centrally-acting migraine preventive drugs suppress frequency and velocity of cortical spreading depression (CSD). The purpose of the current study was to determine how the new class of peripherally acting migraine preventive drug (i.e., the… read more here.
Keywords: propagation; depression; isotype; period ... See more keywords
Class and isotype of VlsE-specific antibody differentiates Lyme disease stage
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DOI: 10.1128/jcm.00347-25
Abstract: ABSTRACT Establishment of immunoglobulin diversity is contingent on recombination that occurs both at the Fab and at the Fc regions of the immunoglobulin, and this process is time dependent. Based on this principle, we questioned… read more here.
Keywords: disease; antibody; stage; class ... See more keywords
Abstract 3121: Therapeutic potential of a HER3 antibody-drug conjugate for the treatment of HER3-expressing cancers
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DOI: 10.1158/1538-7445.am2024-3121
Abstract: To address the need for targeted therapy in the treatment of HER3-positive solid tumors, the human HER3 mAb, seribantumab, was evaluated in the context of an antibody-drug conjugate (ADC). As a proof-of-concept, seribantumab was conjugated… read more here.
Keywords: her3; isotype; patri dxd; her3 adc1 ... See more keywords
Isotype-specific heavy/light chain quantification identifies prognostic biomarkers after ARI0002h BCMA-directed CAR-T cell therapy in multiple myeloma
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-3983
Abstract: ARI0002h (cesnicabtagene autoleucel) is a second-generation humanized BCMA-directed chimeric antigen receptor (CAR) T-cell therapy developed at Hospital Clínic de Barcelona. In a phase II trial, 60 patients with relapsed or refractory multiple myeloma (RRMM) treated… read more here.
Keywords: cell therapy; car cell; day; isotype ... See more keywords