Structural Basis of Analog Specificity in PKG I and II.
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DOI: 10.1021/acschembio.7b00369
Abstract: Cyclic GMP analogs, 8-Br, 8-pCPT, and PET-cGMP, have been widely used for characterizing cellular functions of cGMP-dependent protein kinase (PKG) I and II isotypes. However, interpreting results obtained using these analogs has been difficult due… read more here.
Keywords: structural basis; isotype specificity; pkg; specificity ... See more keywords