Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113511
Abstract: Breast cancer is the second most leading cause of death among women. Multiple drugs have been approved by FDA for the treatment of BC. The major drawbacks of existing drugs are the development of resistance,… read more here.
Keywords: sar studies; isoxazole derivatives; anticancer agent; inhibition ... See more keywords
Design, Synthesis, and Evaluation of Novel Benzo[d]isoxazole Derivatives as Anticonvulsants by Selectively Blocking the Voltage-Gated Sodium Channel NaV1.1.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00846
Abstract: Sodium channel blockers are important antiseizure drugs. Since the launch of phenobarbital in 1912, it has a development history of nearly 100 years. However, because of the confounding symptoms, complications, and complex intrinsic pathogenesis of… read more here.
Keywords: benzo isoxazole; channel; isoxazole derivatives; sodium channel ... See more keywords
Design and synthesis of sinomenine isoxazole derivatives via 1,3-dipolar cycloaddition reaction
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1677649
Abstract: Abstract A novel structure of sinomenine isoxazole derivatives is synthesised from sinomenine hydrochloride and aromatic aldehydes and requires six steps. 19 target compounds have been obtained in good yields. The sinomenine hydrochloride transforms to 4-alkynyl… read more here.
Keywords: isoxazole derivatives; reaction; sinomenine isoxazole; dipolar cycloaddition ... See more keywords