Isocaloric low protein diet in a mouse model for vanishing white matter does not impact ISR deregulation in brain, but reveals ISR deregulation in liver.
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DOI: 10.1080/1028415x.2020.1846356
Abstract: Objective: Vanishing white matter (VWM) is a genetic brain white matter disorder caused by mutations in eIF2B. eIF2B is central in the integrated stress response (ISR), during which its activity is inhibited by various cellular… read more here.
Keywords: vwm; low protein; isr deregulation; deregulation ... See more keywords