Itaconate Has Limited Protective Effects in Experimental Malaria Models
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.202451595
Abstract: In severe malaria, dysregulated metabolism and excessive inflammatory responses contribute to fatal outcomes. Therapeutic strategies that address both metabolic and inflammatory balances are thus required. Itaconate, a metabolite produced by aconitate decarboxylase 1 (ACOD1), is… read more here.
Keywords: limited protective; protective effects; itaconate limited; malaria ... See more keywords
Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a1119-236r
Abstract: The pyruvate dehydrogenase complex (PDC)/pyruvate dehydrogenase kinase (PDK) axis directs the universal survival principles of immune resistance and tolerance in monocytes by controlling anabolic and catabolic energetics. Immune resistance shifts to immune tolerance during inflammatory… read more here.
Keywords: tca cycle; cycle; dehydrogenase complex; pyruvate dehydrogenase ... See more keywords
Brewers' spent grain as carbon source for itaconate production with engineered Ustilago maydis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioresource technology"
DOI: 10.1016/j.biortech.2021.125262
Abstract: Brewers' spent grain (BSG) is produced worldwide in millions of tons during the beer brewing process. Due to its high content of structural carbohydrates, BSG is a promising material for being valorised in biorefineries. In… read more here.
Keywords: grain carbon; bsg; itaconate; spent grain ... See more keywords
New poly(itaconate)s with bulky pendant groups as candidates for “all-polymer” dielectrics
Sign Up to like & getrecommendations! Published in 2019 at "Reactive and Functional Polymers"
DOI: 10.1016/j.reactfunctpolym.2019.04.010
Abstract: Abstract This work presents the synthesis and characterizaiton of three new poly(itaconate)s containing nitriles functional groups as high dipole moment entities and three different cycloalkyl pendant groups, in order to increase the rigidity of the… read more here.
Keywords: poly itaconate; spectroscopy; new poly; pendant groups ... See more keywords
Overcoming Challenges of Incorporation of Biobased Dibutyl Itaconate in (Meth)acrylic Waterborne Polymers
Sign Up to like & getrecommendations! Published in 2024 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.4c00739
Abstract: Polymeric derivatives of itaconic acid are gaining interest as biobased alternatives to petroleum-based monomers due to their versatility, renewable nature, commercial availability, and cost-effectiveness. Itaconate ester monomer’s challenges incorporating in (meth)acrylic waterborne polymers are the… read more here.
Keywords: meth acrylic; incorporation; acrylic waterborne; biobased dibutyl ... See more keywords
The Development and Characterization of Two Monoclonal Antibodies Against the Conjugates and Derivatives of the Immunometabolite Itaconate
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c08552
Abstract: We have developed two monoclonal antibodies, CPTC-2MeSC-1 and CPTC-2MeSC-2, against itaconate and its conjugates with sulfhydryl-containing biomolecules such as cysteines. Itaconate is a dicarboxylic acid metabolite that has recently gained much interest for its anti-inflammatory… read more here.
Keywords: 2mesc cptc; two monoclonal; itaconate; cptc 2mesc ... See more keywords
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/nature25986
Abstract: The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood. Here we show that itaconate is required for the activation of the anti-inflammatory… read more here.
Keywords: anti inflammatory; itaconate anti; itaconate; via alkylation ... See more keywords
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00807-3
Abstract: Itaconate, a metabolite produced during inflammatory macrophage activation, has been extensively described to be involved in immunoregulation, oxidative stress, and lipid peroxidation. As a form of iron and lipid hydroperoxide-dependent regulated cell death, ferroptosis plays… read more here.
Keywords: ferroptosis; lung injury; sepsis induced; itaconate ... See more keywords
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-65582-6
Abstract: Itaconate accumulates in macrophages upon bacterial infection, and manifests antibacterial activity. Convincing evidence substantiates that itaconate is transported across the plasma membrane and vacuolar membrane, but the molecular bases underlying bidirectional transport of itaconate across… read more here.
Keywords: mct1; transport; infection; itaconate ... See more keywords
Itaconate charges down inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-018-0016-4
Abstract: The metabolite itaconate induces electrophilic stress that induces an antioxidant response and regulates secondary TLR transcriptional responses and IL-17-driven pathology. read more here.
Keywords: charges inflammation; itaconate; itaconate charges; immunology ... See more keywords
Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter
Sign Up to like & getrecommendations! Published in 2025 at "Biochemical Journal"
DOI: 10.1042/bcj20253132
Abstract: Pseudomonas aeruginosa PA01 is one of the major causes of disease persistence and mortality in patients with lung pathologies, relying on various host metabolites as carbon and energy sources for growth. The ict-ich-ccl operon (pa0878,… read more here.
Keywords: pseudomonas aeruginosa; dicarboxylate; trap transporter; transporter ... See more keywords