Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a1119-236r
Abstract: The pyruvate dehydrogenase complex (PDC)/pyruvate dehydrogenase kinase (PDK) axis directs the universal survival principles of immune resistance and tolerance in monocytes by controlling anabolic and catabolic energetics. Immune resistance shifts to immune tolerance during inflammatory… read more here.
Keywords: tca cycle; cycle; dehydrogenase complex; pyruvate dehydrogenase ... See more keywords
Brewers' spent grain as carbon source for itaconate production with engineered Ustilago maydis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioresource technology"
DOI: 10.1016/j.biortech.2021.125262
Abstract: Brewers' spent grain (BSG) is produced worldwide in millions of tons during the beer brewing process. Due to its high content of structural carbohydrates, BSG is a promising material for being valorised in biorefineries. In… read more here.
Keywords: grain carbon; bsg; itaconate; spent grain ... See more keywords
New poly(itaconate)s with bulky pendant groups as candidates for “all-polymer” dielectrics
Sign Up to like & getrecommendations! Published in 2019 at "Reactive and Functional Polymers"
DOI: 10.1016/j.reactfunctpolym.2019.04.010
Abstract: Abstract This work presents the synthesis and characterizaiton of three new poly(itaconate)s containing nitriles functional groups as high dipole moment entities and three different cycloalkyl pendant groups, in order to increase the rigidity of the… read more here.
Keywords: poly itaconate; spectroscopy; new poly; pendant groups ... See more keywords
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/nature25986
Abstract: The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood. Here we show that itaconate is required for the activation of the anti-inflammatory… read more here.
Keywords: anti inflammatory; itaconate anti; itaconate; via alkylation ... See more keywords
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00807-3
Abstract: Itaconate, a metabolite produced during inflammatory macrophage activation, has been extensively described to be involved in immunoregulation, oxidative stress, and lipid peroxidation. As a form of iron and lipid hydroperoxide-dependent regulated cell death, ferroptosis plays… read more here.
Keywords: ferroptosis; lung injury; sepsis induced; itaconate ... See more keywords
Itaconate charges down inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-018-0016-4
Abstract: The metabolite itaconate induces electrophilic stress that induces an antioxidant response and regulates secondary TLR transcriptional responses and IL-17-driven pathology. read more here.
Keywords: charges inflammation; itaconate; itaconate charges; immunology ... See more keywords
Effect of pH on the antimicrobial activity of the macrophage metabolite itaconate.
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology"
DOI: 10.1099/mic.0.001050
Abstract: The production of itaconate by macrophages was only discovered in 2011. An increasing number of studies have since revealed essential biological functions for this small molecule, ranging from antimicrobial to immunomodulator. The antibacterial role of… read more here.
Keywords: itaconate; antimicrobial activity; activity; activity macrophage ... See more keywords
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aay0934
Abstract: Itaconate brings metalloenzyme to a halt Controlled radicals enable unusual enzymatic transformations, but radical generation and management require dedicated systems. Ruetz et al. investigated how the immunometabolite itaconate might undermine these intricate systems to inhibit… read more here.
Keywords: itaconate; itaconyl coa; coa; methylmalonyl coa ... See more keywords
Itaconate: an antimicrobial metabolite of macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Canadian Journal of Chemistry"
DOI: 10.1139/cjc-2021-0117
Abstract: Itaconate is a conjugated 1,4-dicarboxylate produced by macrophages. This small molecule has recently received increasing attention due to its role in modulating the immune response of macrophages upon exposure to pathogens. Itaconate has also been… read more here.
Keywords: itaconate; chemistry; antimicrobial metabolite; itaconate antimicrobial ... See more keywords
4-octyl itaconate ameliorate cognitive impairment in 3xTg mouse model of Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732886
Abstract: The most prevalent form of dementia, Alzheimer's disease (AD), is characterized by abnormal amyloid-(A) plaque accumulation, neuroinflammation, and neuronal loss. A cell-permeable derivative of itaconate called 4-octyl itaconate (OI) has recently been shown to reduce… read more here.
Keywords: octyl itaconate; itaconate; alzheimer disease; physiology ... See more keywords
Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010219
Abstract: Excessive inflammation is a major cause of morbidity and mortality in many viral infections including influenza. Therefore, there is a need for therapeutic interventions that dampen and redirect inflammatory responses and, ideally, exert antiviral effects.… read more here.
Keywords: virus infection; interferon responses; infection; influenza virus ... See more keywords