Itaconate derivative 4-OI inhibits M1 macrophage polarization and restores its impaired function in immune thrombocytopenia through metabolic reprogramming
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DOI: 10.1097/cm9.0000000000003586
Abstract: Abstract Background: Macrophage polarization anomalies and dysfunction play a crucial role in the pathogenesis of immune thrombocytopenia (ITP). Itaconate is a Krebs cycle-derived immunometabolite synthesized by myeloid cells to modulate cellular metabolism and inflammatory responses.… read more here.
Keywords: itaconate derivative; macrophage polarization; immune thrombocytopenia; macrophage ... See more keywords