Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair
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DOI: 10.1126/science.aay0934
Abstract: Itaconate brings metalloenzyme to a halt Controlled radicals enable unusual enzymatic transformations, but radical generation and management require dedicated systems. Ruetz et al. investigated how the immunometabolite itaconate might undermine these intricate systems to inhibit… read more here.
Keywords: itaconate; itaconyl coa; coa; methylmalonyl coa ... See more keywords