Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density
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DOI: 10.1126/scisignal.aan1088
Abstract: Modeling the responses of synthetic receptors in T cells identifies new ways to optimize CAR–T cell activity. ITAM abundance increases receptor potency T cells transduce extracellular signals by phosphorylating immunoreceptor tyrosine-based activation motifs (ITAMs) within… read more here.
Keywords: potency selectivity; potency; receptor; cell ... See more keywords