Spinal IL‐33/ST2 signaling mediates chronic itch in mice through the astrocytic JAK2‐STAT3 cascade
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DOI: 10.1002/glia.23639
Abstract: Interleukin‐33 (IL‐33) and its receptor ST2 contribute to spinal glial activation and chronic pain. A recent study showed that peripheral IL‐33 plays a pivotal role in the pathogenesis of chronic itch induced by poison ivy.… read more here.
Keywords: itch; spinal st2; chronic itch; st2 signaling ... See more keywords
Keratinocyte TLR2 and TLR7 contribute to chronic itch through pruritic cytokines and chemokines in mice
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DOI: 10.1002/jcp.30923
Abstract: Although neuronal Toll‐like receptors (TLRs) (e.g., TLR2, TLR3, and TLR7) have been implicated in itch sensation, the roles of keratinocyte TLRs in chronic itch are elusive. Herein, we evaluated the roles of keratinocyte TLR2 and… read more here.
Keywords: keratinocyte tlr2; tlr2 tlr7; itch; chronic itch ... See more keywords
Use of Butorphanol as Treatment for Cholestatic Itch
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DOI: 10.1007/s10620-020-06392-2
Abstract: Background Pruritus is a debilitating symptom of cholestatic diseases such as primary biliary cholangitis and primary sclerosing cholangitis and often results in major reduction in quality of life for afflicted patients. Classic treatment options for… read more here.
Keywords: itch; butorphanol; treatment; pruritus ... See more keywords
Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.
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DOI: 10.1016/j.bcp.2022.114972
Abstract: Despite accumulating evidence in rodents, the functional role of neuromedin B (NMB) in regulating somatosensory systems in primate spinal cord is unknown. We aimed to compare the expression patterns of NMB and its receptor (NMBR)… read more here.
Keywords: gastrin releasing; itch pain; itch; spinal cord ... See more keywords
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
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DOI: 10.1016/j.cell.2017.08.006
Abstract: Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to expel invading pathogens and noxious environmental stimuli. It is well established that these responses are also associated with chronic inflammatory diseases, including asthma and… read more here.
Keywords: signaling pathways; itch; classical immune; immune signaling ... See more keywords
A basophil-neuronal axis promotes itch
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DOI: 10.1016/j.cell.2020.12.033
Abstract: Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory disorders such as atopic dermatitis (AD), itch becomes chronic, intractable,… read more here.
Keywords: acute itch; itch; axis promotes; basophil neuronal ... See more keywords
Basophils add fuel to the flame of eczema itch
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DOI: 10.1016/j.cell.2020.12.035
Abstract: Children and adults with atopic dermatitis suffer from intractable chronic itch and can also experience acute itch flare ups that significantly increase itch intensity. In this issue of Cell, Wang et al. demonstrate that a subset… read more here.
Keywords: eczema itch; itch; fuel flame; flame eczema ... See more keywords
Nppb Neurons Are Sensors of Mast Cell-Induced Itch
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DOI: 10.1016/j.celrep.2019.02.089
Abstract: SUMMARY Itch is an unpleasant skin sensation that can be triggered by exposure to many chemicals, including those released by mast cells. The natriuretic polypep-tide b (Nppb)-expressing class of sensory neurons, when activated, elicits scratching… read more here.
Keywords: itch; cell induced; nppb neurons; induced itch ... See more keywords
Causes, pathophysiology, and treatment of pruritus in the mature patient.
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DOI: 10.1016/j.clindermatol.2017.10.005
Abstract: Chronic itch is a common and debilitating health condition in the elderly. There are several common causes of itch in the mature population, such as skin xerosis, immunosenescence, and neuropathic changes. In addition, skin diseases,… read more here.
Keywords: mature; causes pathophysiology; itch; pathophysiology treatment ... See more keywords
Cognitive Schemas in Placebo and Nocebo Responding: Role of Autobiographical Memories and Expectations.
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DOI: 10.1016/j.clinthera.2017.02.004
Abstract: PURPOSE Placebo effects are presumed to be based on one's expectations and previous experience with regard to a specific treatment. The purpose of this study was to investigate the role of the specificity and valence… read more here.
Keywords: itch; placebo nocebo; cognitive schemas; role ... See more keywords
Barbiturates enhance itch‐associated scratching in atopic dermatitis mice: A possible clue to understanding nocturnal pruritus in atopic dermatitis
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DOI: 10.1016/j.ejphar.2018.08.018
Abstract: Abstract In chronic pruritic diseases such as atopic dermatitis, pruritus is exacerbated during nocturnal sleep; however, the underlying mechanism remains unclear. We previously demonstrated that acute administration of the sedative‐hypnotics ethanol markedly enhanced itch‐associated spontaneous… read more here.
Keywords: itch; atopic dermatitis; scratching atopic; receptor ... See more keywords