1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma.
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DOI: 10.1016/j.ejmech.2017.09.011
Abstract: A series of 1,4-naphthoquinones (10a-10q) were synthesized and evaluated for anticancer activity. Compound 10e was identified as an inhibitor of Itch, a HECT domain-E3 ligase. In an evaluation of in vivo efficacy, 10e exhibited remarkable anticancer… read more here.
Keywords: multiple myeloma; domain ligase; hect domain; itch hect ... See more keywords