Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.00105
Abstract: M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In… read more here.
Keywords: itch; neuronal excitability; itch mice; induced itch ... See more keywords
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214321
Abstract: Chloroquine (CQ) is an antimalaria drug that has been widely used for decades. However, CQ-induced pruritus remains one of the major obstacles in CQ treatment for uncomplicated malaria. Recent studies have revealed that MrgprX1 plays… read more here.
Keywords: induced pruritus; induced itch; mrgprx1; berbamine ... See more keywords