Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.114972
Abstract: Despite accumulating evidence in rodents, the functional role of neuromedin B (NMB) in regulating somatosensory systems in primate spinal cord is unknown. We aimed to compare the expression patterns of NMB and its receptor (NMBR)… read more here.
Keywords: gastrin releasing; itch pain; itch; spinal cord ... See more keywords
Modulation of itch and pain signals processing in ventrobasal thalamus by thalamic reticular nucleus
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DOI: 10.1016/j.isci.2021.103625
Abstract: Summary Thalamic reticular nucleus (TRN) is known to be crucial for dynamically modulating sensory processing. Recently, the functional role of TRN in itch and pain sensation processing has drawn much attention. We found that ventrobasal… read more here.
Keywords: thalamic reticular; reticular nucleus; pain; itch pain ... See more keywords
Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons
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DOI: 10.1016/j.neuron.2020.03.021
Abstract: Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the… read more here.
Keywords: itch; differential coding; subpopulation; itch pain ... See more keywords
A compound offers itch and pain relief without side effects
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/d41586-018-05957-6
Abstract: Brain-cell experiments reveal the molecular roots of a potential drug’s unusual advantage.Brain-cell experiments reveal the molecular roots of a potential drug’s unusual advantage. read more here.
Keywords: offers itch; relief without; pain relief; itch pain ... See more keywords
Anatomical and Functional Dichotomy of Ocular Itch and Pain
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DOI: 10.1038/s41591-018-0083-x
Abstract: Itch and pain are refractory symptoms of many ocular conditions. Ocular itch is generated mainly in the conjunctiva and is absent from the cornea. In contrast, most ocular pain arises from the cornea. However, the… read more here.
Keywords: ocular itch; itch; sensory fibers; anatomical functional ... See more keywords
Neuropathic pain and itch: mechanisms in allergic conjunctivitis
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000843
Abstract: Purpose of review Allergic conjunctivitis is highly prevalent and affects up to one third of the general population. The current understanding of the pathophysiology and therapeutic strategies center around the type 2 inflammatory pathway. However,… read more here.
Keywords: itch pain; itch; pain itch; allergic conjunctivitis ... See more keywords
Itch and pain by lesion morphology in hidradenitis suppurativa patients
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Dermatology"
DOI: 10.1111/ijd.15037
Abstract: Haruki Mizuta , MD Kenjiro Namikawa *, MD, PhD Akira Takahashi , MD, PhD Dai Ogata , MD, PhD Yusuke Muto , MD Shunichi Jinnai , MD Kenta Nakama , MD Keita Tsutsui , MD… read more here.
Keywords: pain lesion; phd; hidradenitis suppurativa; lesion morphology ... See more keywords
Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex
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DOI: 10.5607/en22029
Abstract: Itch and pain are distinct sensations that share anatomically similar pathways: from the periphery to the brain. Over the last decades, several itch-specific neural pathways and molecular markers have been identified at the peripheral and… read more here.
Keywords: itch pain; itch; pain; primary somatosensory ... See more keywords