ACC010, a novel BRD4 inhibitor, synergized with homoharringtonine in acute myeloid leukemia with FLT3-ITD.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13368
Abstract: Bromodomain-containing protein 4 (BRD4) inhibitors have been clinically developed to treat acute myeloid leukemia (AML), but their application is limited by the possibility of drug resistance, which is reportedly associated with the activation of the… read more here.
Keywords: itd; acc010; hht; brd4 ... See more keywords
An Implantable Magnetic Vascular Scaffold for Circulating Tumor Cell Removal In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202207870
Abstract: An integrated trapped device (ITD) capable of removal of circulating tumor cells (CTCs) can assuage or even prevent metastasis. However, adhesion repertoires are ordinarily neglected in the design of ITDs, possibly leading to the omission… read more here.
Keywords: circulating tumor; vascular; itd; vivo ... See more keywords
Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.03.046
Abstract: FLT3-ITD and FLT3-TKD are the most frequent mutations in acute myeloid leukemia (AML) with the former associated with a poor prognosis. Here we show that inhibition of the deubiquitinase USP9X by its inhibitor WP1130 or… read more here.
Keywords: flt3 itd; itd; positive aml; itd positive ... See more keywords
Neuronal sensitivity to the interaural time difference of the sound envelope in the mouse inferior colliculus
Sign Up to like & getrecommendations! Published in 2020 at "Hearing Research"
DOI: 10.1016/j.heares.2019.107844
Abstract: We examined the sensitivity of the neurons in the mouse inferior colliculus (IC) to the interaural time differences (ITD) conveyed in the sound envelope. Utilizing optogenetic methods, we compared the responses to the ITD in… read more here.
Keywords: envelope; sensitivity; inferior colliculus; interaural time ... See more keywords
The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01462-4
Abstract: FLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts to better understand FLT3-ITD downstream signaling to possibly improve therapy response… read more here.
Keywords: flt3 itd; itd; positive aml; itd positive ... See more keywords
FLT3‐ITD DNA and mRNA levels in AML do not correlate with CD7, CD33 and CD123 expression
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15255
Abstract: FLT3 internal tandem duplication (ITD) mutations are found in around 25% of all acute myeloid leukaemia (AML) cases and is associated with shorter disease‐free and overall survival. Previous reports have shown that FLT3‐ITD induces a… read more here.
Keywords: flt3 itd; itd; cd123 expression; cd33 cd123 ... See more keywords
Comparisons of electric and acoustic ITD coding in normal hearing gerbils
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Acoustical Society of America"
DOI: 10.1121/1.5035842
Abstract: Small differences in the arrival time of sound between the two ears [interaural time differences (ITDs)] provide important cues for directional hearing and speech understanding in noise. Deaf subjects with bilateral cochlear implants (CIs) show… read more here.
Keywords: normal hearing; hearing gerbils; electric acoustic; acoustic itd ... See more keywords
Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukaemia.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-0738
Abstract: Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of poor prognosis acute myeloid leukaemias (AMLs). Limited clinical efficacy of FLT3 inhibitors highlights the need for alternative therapeutic modalities in… read more here.
Keywords: serine biosynthesis; flt3 itd; itd; acute myeloid ... See more keywords
NGS-Based Monitoring of Measurable Residual Disease in FLT3-ITD Positive Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-113382
Abstract: Background: In acute myeloid leukemia (AML), most patients respond to chemotherapy initially, but the risk of relapse remains high. Continued monitoring of measurable residual disease (MRD) following therapy onset enables early assessment of treatment response… read more here.
Keywords: relapse; monitoring; speakers bureau; flt3 itd ... See more keywords
FLT3 inhibition upregulates HDAC8 via FOXO to inactivate p53 and promote maintenance of FLT3-ITD+ acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019003538
Abstract: Internal tandem duplication (ITD) mutations within the FMS-like receptor tyrosine kinase-3 (FLT3) can be found in up to 25~30% of acute myeloid leukemia (AML) patients and confer a poor prognosis. Although FLT3 tyrosine kinase inhibitors… read more here.
Keywords: maintenance; inhibition; flt3 itd; itd ... See more keywords
TP-0903, a Novel Axl Inhibitor with Activity in Drug Resistant FLT3-ITD+ AML through a Mechanism That Includes FLT3 Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.2522.2522
Abstract: Abnormal expression of receptor tyrosine kinase Axl has been associated with poor prognosis in different cancers including acute myeloid leukemia (AML) and has been linked to drug resistance against chemotherapy as well as targeted therapies… read more here.
Keywords: flt3; flt3 itd; itd; itd aml ... See more keywords