Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo
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DOI: 10.1038/s41375-021-01490-0
Abstract: Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In vitro studies implicated Grb2-associated binder 2 (GAB2) as… read more here.
Keywords: gab2; acute myeloid; flt3 itd; myeloid leukemia ... See more keywords