Domino Semipinacol/Iterative Aldol/Iso-Nazarov Cyclization to Triaryl-cyclopentenone: Enantioselective Synthesis of Combretastatin A-4 Analogues.
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DOI: 10.1021/acs.orglett.2c01531
Abstract: A facile domino strategy has been developed for the synthesis of a biologically active cyclopent-2-enone core containing combretastatin A-4 (CA-4) analogues from aryloxirane and aryl aldehyde. This one-pot method involves a sequence of semipinacol rearrangement,… read more here.
Keywords: nazarov cyclization; enantioselective synthesis; iterative aldol; combretastatin analogues ... See more keywords